Friday 21 June 2013

Instant View: Fed to keep buying bonds, boosts 2014 forecasts

(Reuters) - The Federal Reserve on Wednesday said it would keep buying $85 billion in bonds per month and gave no explicit indication that it was close to scaling back the program, despite intense market speculation it could soon start drawing it to a close.

KEY POINTS: * Describing the economy as expanding moderately, Fed officials cited further improvement in labor market conditions, and noted inflation had been running below the Fed's 2 percent long term goal. * They also reiterated that unemployment is still too high for their comfort, reinforcing their desire to keep buying assets until the outlook for jobs improves substantially, but offered a slightly more upbeat assessment of the balance of risks to the nation's growth. * In fresh quarterly projections, 14 of the 19 members of the Fed's policy-setting committee said they did not think it would be appropriate to raise rates until sometime in 2015. * Three officials saw 2014 as the year that rates would lift off from near zero, versus four policymakers back in March. One official continued to anticipate the first rate hike in 2016 and one in 2013.

COMMENTS:

BRIAN LEVITT, SENIOR ECONOMIST AT OPPENHEIMERFUNDS IN NEW YORK, NY:

"The Fed is obviously more optimistic than they had otherwise been about the U.S. economy and I think it confirms a lot of the better economic conditions that we had been seeing too.

"Certainly the Treasury market is telling us something. The Fed does not appear to be as worried about things as they had suggested in prior statements and that signals to the market that they are taking somewhat of a more hawkish tone.

"They're more sanguine about U.S. economic growth and they're less likely to be dovish on monetary policy. I would view this as good news. It's a long process of normalization, it doesn't mean tight conditions overnight, and the fundamentals of the equity market still look reasonable.

"I don't think investors should be eliminating equity positions because the Fed is beginning a long process of policy normalization.

"Investors always freak out at what looks like a sea change in policy, but typically policy normalization and or tightening is coincident with improving macro conditions and a generally healthy environment for stocks.

"It's a slight change in language that suggests that the Fed is more optimistic than they were in the May statement. After Bernanke's comments a few week ago suggesting that tapering could be in the offing, that's what the market's trying to price in."

MICHAEL MATOUSEK, HEAD TRADER AT U.S. GLOBAL INVESTORS INC., SAN ANTONIO, TEXAS:

"Right when it first came out I think everyone was shooting first and asking questions later because you had gold selloff, you had the dollar rally, and you had 10-year yields pop up. So basically with the yields going up that means people are selling off their bonds, they want to own the dollar, and they're not looking at gold right now.

"It seems like a lot right now, that the S&P is down 92 basis points, some people are saying ?wow the S&P is getting hit,' but when you really look at it, last year this would have been a normal move for the S&P. It's still a positive for the economy. I don't think it's going to derail anything in that respect.

"The S&P came to the 1608 level since the beginning of June and bounced back from there, so if it does pull back you're going to see market participants come back and start building. It's a good level, people aren't chasing the market as much as they were the past few months of the year.

"I think people are looking for a reason to sell stuff? Odds are, they're going to start nibbling again when the market pulls back."

KEN MAYLAND, PRESIDENT, CLEARVIEW ECONOMICS, PEPPER PIKE, OHIO:

"Is the economy achieving even average growth? Are payrolls expanding 200,000 per month on a sustained basis? Are prices rising too fast, and expectations of price increases exceeding target rates? No, no, no! So forget about 'tapering' for at least the next few months. The financial markets are over-thinking this. Extreme accommodation, in the form of super-low short-term interest rates, is likely to remain in effect for an extremely long period of time."

STEPHEN MASSOCCA, MANAGING DIRECTOR, WEDBUSH EQUITY MANAGEMENT LLC IN SAN FRANCISCO:

"You would think everything he would be saying would be good for bonds, not bad for bonds. This started well before he started speaking. It's beyond me. I could see if the taper had begun. The only thing I could think of is that people were positioned to short the dollar and they used the proceeds from being short the dollar to be long bonds and somehow they see this is as being positive for the dollar. But none of this makes any sense - it's almost the opposite of what is expected.

"The minute the news came out the bond market went down. This has been driven by the bond market, that is what is driving the stock market. There is no reason for the stock market to be down other than the fact the bond market has turned around. All these dividend-paying stocks are getting hit and a lot of people who are panicking out of places they have been to collect yield and people are concerned that maybe those spaces are too overcrowded. If you are unhedged today your hair is on fire."

AXEL MERK, PRESIDENT AND CHIEF INVESTMENT OFFICER, MERK INVESTMENTS, PALO ALTO, CALIFORNIA:

"The main news is that they do indeed plan to taper purchases later this year and hope to be done by next summer. Bernanke wants to communicate that this is not necessarily tightening, but the market may not see it that way. But remember, their forecasts are rarely accurate. So this may be them engaging in the same wishful thinking as everybody else. We'll have to see whether the numbers cooperate. What we do know is that inflation expectations are coming down with a vengeance and the employment is not improving at a very strong pace."

FRED DICKSON, CHIEF MARKET STRATEGIST, D.A. DAVIDSON & CO., LAKE OSWEGO:

"He took off the table the possibility of tapering in September, but his comments about the possibility of slowing down rate of asset purchases toward the end of the year and eliminating them by mid-year provided some clarity... but may have caused a little bit of surprise.

"He gave the first clue as to when possibly the asset purchase program might stop, and that was the catalyst that caused the market reaction."

JOSEPH GRECO, MANAGING DIRECTOR AT MERIDIAN EQUITY PARTNERS IN NEW YORK:

The selloff is "clearly a reaction to Fed's affirmation that with improvements in employment and the economy it would appear possible that they would mostly likely pursue a varied pace of asset purchasing by the end of this year."

FRANK MCGHEE, HEAD PRECIOUS METALS TRADER, INTEGRATED BROKERAGE SERVICES LLC, CHICAGO:

"The statement indicates that the economy is on the mend, and the Fed is expecting lower than previously projected levels of inflation. You are looking at continued slow growth but no inflation and no panic on the horizon, that makes gold less attractive and ultimately makes stocks more attractive."

ROB LUTTS, PRESIDENT AND CIO, CABOT MONEY MANAGEMENT, SALEM, MASSACHUSETTS:

"The most surprising thing was the raising of the growth rate for 2014. They took it up a healthy notch. That's telling you they see a pattern of continued strength that will continue to move forward into next year.

"Widely expected they were to going to talk about tapering and a September/October time frame for easing off bond purchases. That maybe is helpful to the market that it is not immediately around the corner. Maybe people are thinking it is 2014 rather than 2013 but clearly it is coming.

"The growth figure is what the bond market is going to focus on most and bond participants are saying if the Fed is correct we have to start thinking higher rates in the near term.

"They punted on tapering. They know the market expects it and if the market needed to hear more they would have said something. I believe they feel the market has tapering fully in it. By raising the growth number they have effectively done a similar thing. That is a stronger communication. Many economists have a slower recovery in place and it means maybe a more normal economic environment next year."

GREG MCBRIDE, SENIOR FINANCIAL ANALYST, BANKRATE.COM, NEW YORK:

"Interestingly there is greater dissent being voiced within the voting members of the committee, the new vote against actually indicating potentially a desire for even more stimulus to defend the inflation goal. It clearly balances out that hawkish dissent, particularly at a time when the economy is still not where the Fed wants it to be, and gives them a case to maintain the pace of stimulus throughout the summer months.

"The statement contained a notable pat on the back, saying the downside risks to the outlook for the economy and the labor market have diminished since the fall, which is a necessary precursor if they are going to get to the point where they do start to taper."

GEORGE RUSNAK, NATIONAL DIRECTOR OF FIXED INCOME FOR WELLS FARGO PRIVATE BANK IN PHILADELPHIA:

"Clearly it seems like the Fed is signaling they will begin tapering. They are either going to start in either the fourth quarter or the first quarter of next year, but that is going to happen. The idea of when that happens is going to be the first sign of trying to ease into that process.

"The fact they brought in the conversation around unemployment potentially hitting their target towards the year-end of 2014. That maybe not necessarily spooked the bond market but may have given an idea to the bond market that not only are they talking about removing themselves from QE but potentially removing themselves from a zero interest rate policy at the end of next year."

CAMILLA SUTTON, CHIEF CURRENCY STRATEGIST, SCOTIABANK, TORONTO:

"I think the FX reaction was due to the upgrade in employment forecasts. The forecasts suggested that the unemployment rate will fall to 6.5 percent in 2014, which means that the Fed could hike rates sooner than expected, possibly as early as the first quarter of 2015. And that's positive for the U.S. dollar."

IAN LYNGEN, SENIOR GOVERNMENT BOND STRATEGIST, CRT CAPITAL GROUP, STAMFORD, CONNECTICUT:

"The net takeaway was the fact that they didn't offer anything specific on the timing for tapering QE. We had a new dissenter, being Bullard, who's now dissenting from the dovish side. He's more worried about inflation. However, in the statement the Fed characterized the benign inflation as partially reflecting transitory influences but reiterated inflation expectations remain stable.

"They also upgraded the economic outlooks and said that the committee views the downside risks for the economy and the labor market as having diminished since the fall? That simply means lower than they were in the fall. I think that is what people are looking at as a bit more hawkish in there and within the projections, I would say that the surprise for us at least was the fact that they lowered the unemployment rate forecast pretty significantly, suggesting that they believe that the improvements are going to be sustainable and implicitly that as the labor market accelerates, the labor participation rate will not increase at a pace to put upward pressure on the unemployment rate."

FRANK LESH, FUTURES ANALYST AND BROKER, FUTUREPATH TRADING LLC, CHICAGO:

"The thing that I noticed really so far was the fact that downside risks to the economy are diminishing. That to me would imply that we're closer to the Fed reducing its support for the economy, and that's all we know so far."

DAN DORROW, HEAD OF RESEARCH, FAROS TRADING, STAMFORD, CONNECTICUT:

"What was surprising was the change in 2014 forecasts for unemployment. They've also said the downside risks to the outlook have reversed. So they are slightly more constructive on the economy, and the unemployment call would move forward the first fed funds rate hike, which is still way out there but has been moved forward slightly. This is going to push yields up. We're seeing them rise at the shorter end of the curve, too, so you'd expect the dollar to go higher, especially against the euro and sterling."

BUCKY HELLWIG, SENIOR VICE PRESIDENT AT BB&T WEALTH MANAGEMENT IN BIRMINGHAM, ALABAMA:

"I think still today the driving event will be what Ben Bernanke says, but with regard to the statement, it was a positive from the standpoint that they're going to continue to buy at the $85 billion level, but some of the statements in there suggest that things are setting up for a taper at some point, and that's kind of when the (stock) market went the other way.

"The suggestion that economic activity has been expanding at a moderate pace and that labor markets show further improvements, I think market participants are reading that the economy is improving perhaps enough to put in some curtailment of the purchases later on... The more optimistic outlook on the economy, it looks like traders view that as tapering being closer rather than farther in terms of the calendar."

ENRIQUE ALVAREZ, LATIN AMERICA STRATEGIST, IDEAGLOBAL, NEW YORK:

"The U.S. is seeing stronger growth and somewhat lower unemployment projections. This means that this view that THEY are going to move up the curtailment of asset purchases is still on the table, it is not completely removed.

"As long as that is on the table it guarantees that Latin America is going to continue to see volatility in the markets, and the defensive stance of carry trades in the currency market is going to remain intact."

MIKE KASTNER, HEAD OF FIXED INCOME AT HALYARD ASSET MANAGEMENT IN WHITE PLAINS, NEW YORK:

"The statement was a little more dovish in the comments than I thought it would be. Long-dated Treasuries sold off. That was the story of the old bond vigilantes saying if the statement is more dovish, then inflation is more likely to be a problem down the road so get in front of that now by selling the bond and increasing the inflation premium.

"We will get a better sense of the timing of the tapering during the press conference as to whether it might occur in the next couple of FOMC meetings or whether it's pushed out to later this year or next year.

"The Bullard vote was a little bit of a surprise. That's why I consider it to be a net dovish statement."

VASSILI SEREBRIAKOV, CURRENCY STRATEGIST, BNP PARIBAS, NEW YORK:

"The markets are reacting to the more positive economic assessment in the statement, notably the comment that economic risks have diminished. I think it's being seen as a signal that the Fed is close to tapering. U.S. yields are higher and they're pushing the dollar higher as well against the other funding currencies such as the Japanese yen. Obviously we'll have to wait till the press conference to get any additional details on the tapering."

PARESH UPADHYAYA, HEAD OF CURRENCY STRATEGY, PIONEER INVESTMENTS, BOSTON:

"It's hawkish. They talked about the labor market showing improvement and that the downside risks have diminished since autumn. That reflects the fact that the fiscal tightening has not hurt as much as they had feared. The forecasts are significant, too. Not only is their outlook for 2014 better but their unemployment call has the jobless rate possibly hitting 6.5 percent in 2014. Depending on what Bernanke adds later, I think we'll be off to the races when it comes to higher Treasury yields and a higher dollar, especially against the yen. And we should see a sell-off in risky assets."

RICK MECKLER, LIBERTYVIEW CAPITAL MANAGEMENT LLC, JERSEY CITY, NEW JERSEY:

On the fall in stocks: "There's no change in the program. I would not be surprised to see a round-trip here where the first reaction is down because there's almost nothing that's going to change the ultimate move, which will eventually be to taper. What investors will need on the other side is just some evidence that's offset by economic growth. That's been missing lately."

TOM PORCELLI, CHIEF U.S. ECONOMIST, RBC CAPITAL MARKETS, NEW YORK:

"There were really no significant changes to the Fed statement, although they modestly improved their assessment of the labor market. Overall this was a net neutral statement and the meat of the market's reaction should come from the press conference."

IRA JERSEY, INTEREST RATE STRATEGIST, CREDIT SUISSE, NEW YORK:

"The statement disappointed a little, in that it made it sound like they are going to taper. They are not worried about the market's outlook for lower inflation, so they kind of ignored the TIPS market. Simultaneously they lowered their forecast for the unemployment rate a little bit, so in effect they may have pulled forward some people's expectations of a hike just a little bit. That's one of the reasons you are seeing the selloff in Treasuries that we are seeing, particularly in the belly of the curve."

RANDY FREDERICK, MANAGING DIRECTOR OF ACTIVE TRADING AND DERIVATIVES, CHARLES SCHWAB, AUSTIN, TEXAS:

"The interesting thing is that the VIX is lower when the market is lower. I don't think we saw anything that was surprising so far from the Fed and I don't really think that market was expecting anything new because you would really see institutions buying VIX puts and calls if they thought things would be uncertain. That wasn't the case. For now, it's nothing too surprising, but we would have to wait until Bernanke press conference."

TANWEER AKRAM, SENIOR ECONOMIST, ING, ATLANTA, GEORGIA:

"The statement is as expected in the sense that the FOMC acknowledged improvement in labor markets but acknowledged that the unemployment rate is still elevated and that fiscal policy is likely to restrain growth. It maintained its commitment to asset purchases conditional on the data. A bit different was there was a dovish vote by James Bullard stating the FOMC should be more accommodative in light of inflation undershooting the Fed's long-term target."

MARK LUSCHINI, CHIEF INVESTMENT STRATEGIST AT JANNEY MONTGOMERY SCOTT IN PHILADELPHIA:

"There's no great surprise, and this is something of a non-event statement. It didn't spook markets in terms of advancing notions of tapering, but it largely leans towards deferring that tapering until later this year. The fact that this is status quo is enough to put a little pressure on the market, largely because of the run-up we've seen over the past few days.

"It is interesting that Bullard voted to dissent against any altering of the policy, that bodes towards the idea that there will be tapering later this year."

MARKET REACTION:

STOCKS: U.S. stock indexes were modestly lower

BONDS: U.S. bond prices dipped, particularly long-dated bonds

FOREX: The dollar gained against the yen and euro

(Americas Economics and Markets Desk; +1-646 223-6300)

Source: http://news.yahoo.com/instant-view-fed-keep-buying-bonds-boosts-2014-053257293.html

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Thursday 20 June 2013

Obama renews calls for nuclear reductions

BERLIN (AP) ? Appealing for a new citizen activism in the free world, President Barack Obama renewed his call Wednesday to reduce U.S. and Russian nuclear stockpiles and to confront climate change, a danger he called "the global threat of our time."

In a wide-ranging speech that enumerated a litany of challenges facing the world, Obama said he wanted to reignite the spirit that Berlin displayed when it fought to reunite itself during the Cold War.

"Today's threats are not as stark as they were half a century ago, but the struggle for freedom and security and human dignity, that struggle goes on," Obama said at the city's historic Brandenburg Gate under a bright, hot sun. "And I come here to this city of hope because the test of our time demands the same fighting spirit that defined Berlin a half-century ago."

The president called for a one-third reduction of U.S. and Russian deployed nuclear weapons, saying it is possible to ensure American security and a strong deterrent while also limiting nuclear weapons.

Obama's address comes nearly 50 years after John F. Kennedy's famous Cold War speech in this once-divided city. Shedding his jacket and at times wiping away beads of sweat, the president stood behind a bullet-proof pane and addressed a crowd of about 4,500, reading from paper because the teleprompter wasn't working.

It was a stark contrast to the speech the president delivered in the city in 2008, when he summoned a crowd of 200,000 to embrace his vision for American leadership. Whereas that speech soared with his ambition, this time Obama came to caution his audience not to fall into self-satisfaction.

"Complacency is not the character of great nations," Obama insisted.

"Today," he said, "people often come together in places like this to remember history, not to make it. Today we face no concrete walls or barbed wire."

The speech came just one week shy of the anniversary of Kennedy's famous Cold War speech in which he denounced communism with his declaration "Ich bin ein Berliner" (I am a Berliner). Obama, clearly aware that he was in Kennedy's historic shadow, asked his audience to heed the former president's message.

"If we lift our eyes as President Kennedy calls us to do, then we'll recognize that our work is not yet done," he said. "So we are not only citizens of America or Germany, we are also citizens of the world."

Obama spoke repeatedly of seeking "peace with justice" around the world by confronting intolerance, poverty, Middle East conflicts and economic inequality.

But even before his speech, White House aides were drawing attention to his call for nuclear reductions, casting it as the centerpiece of his address.

"Peace with justice means pursuing the security of a world without nuclear weapons, no matter how distant that dream may be," Obama said.

"We can ensure the security of America and our allies and maintain a strong and credible strategic deterrent while reducing our deployed strategic nuclear weapons by up to one-third," he said.

Signaling a new effort to pick up his delayed environmental agenda, Obama also issued a call to tackle climate change, an issue he has promised to make a priority since his 2008 presidential campaign.

"Peace with justice means refusing to condemn our children to a harsher, less hospitable planet," he said.

He said the U.S. has expanded renewable energy from clean sources and is doubling automobile fuel efficiency. But he said that without more action by all countries, the world faces what he called a grim alternative of more severe storms, famine, floods, vanishing coastlines and displaced refugees.

"This is the future we must avert," he said. "This is the global threat of our time."

Among those in the audience, Doro Zinke, president of the Berlin-Brandenburg trade union federation, said she heard nothing unexpected in Obama's speech.

"I think he's really got to deliver now," she said.

But others gave him credit for just coming to Berlin, five years into his presidency.

"The most important message here was that he came to Berlin and spoke to us and the world," said Catharina Haensch, a Berliner born in the communist east of the city who now works for the Fulbright Commission. "Even If it looks like he isn't able to fulfill all of his promises, you've got to keep on hoping."

Obama and his wife, Michelle, attended an official dinner hosted by Merkel and her husband, Joachim Sauer, at the Schloss Charlottenburg palace to cap their day.

In his earlier speech, the president said he intends to seek negotiated cuts to deployed nuclear weapons with Russia, thus steering away from any unilateral U.S. reductions. Moreover, Obama said he would work with NATO allies to seek "bold reductions" in U.S. and Russian tactical weapons in Europe. Obama could face objections among NATO countries where many strongly oppose removing U.S. nuclear weapons because they worry that the Russians have a far greater number of tactical nuclear weapons within range of their territory.

In Washington, reaction was mixed.

Rep. Adam Smith of Washington state, the top Democrat on the House Armed Services Committee, welcomed Obama's announcement, saying that reducing nuclear weapons "will improve our national security, while maintaining our nuclear triad and our ability to deter and respond to any perceived or real nuclear threat.

But Rep. Michael Turner, R-Ohio, also a member of the Armed Services Committee, accused Obama of appeasement in endorsing further reductions in nuclear weapons, saying the president "seems only concerned with winning the approval of nations like Russia, who will applaud a weakened United States."

Sen. Bob Corker of Tennessee, the top Republican on the Foreign Relations Committee, said Secretary of State John Kerry called him on Tuesday and reassured him that any further reductions in nuclear weapons would not be done unilaterally. Rather, the cuts would be part of treaty negotiations subject to a Senate vote.

Corker criticized Obama's move without additional modernization of the arsenal.

"The president's announcement without first fulfilling commitments on modernization could amount to unilateral disarmament," Corker said. "The president should follow through on full modernization of the remaining arsenal and pledges to provide extended nuclear deterrence before engaging in any additional discussions."

The president discussed non-proliferation with Russian President Vladimir Putin when they met Monday on the sidelines of the Group of 8 summit in Northern Ireland. During Obama's first term, the U.S. and Russia agreed to limit their deployed weapons to 1,550 as part of the New START Treaty.

In Moscow, Russian foreign policy aide Yuri Ushakov said that plans for any further arms reduction would have to involve countries beyond Russia and the United States.

"The situation is now far from what it was in the '60s and '70s, when only the U.S.A. and the Soviet Union discussed arms reduction," Ushakov said.

Alexei Pushkov, head of the Duma's foreign affairs committee, told the Interfax news agency the president's proposals need "serious revision so that they can be seen by the Russian side as serious and not as propaganda proposals."

Obama's calls for cooperation with Moscow come at a time of tension between the U.S. and Russia, which are supporting opposite sides in Syria's civil war. Russia also remains wary of U.S. missile defense plans in Europe, despite U.S. assurances that the shield is not aimed at Moscow.

Germany's foreign minister, Guido Westerwelle, is a strong advocate of nuclear disarmament and has long called for the removal of the last U.S. nuclear weapons from German territory, a legacy of the Cold War. The Buechel Air Base in western Germany is one of a few remaining sites in Europe where they are based.

Under an agreement drawn up when they formed a coalition government in 2009, German Chancellor Angela Merkel's conservatives and Westerwelle's Free Democratic Party agreed to press NATO and Washington for the nuclear weapons to be withdrawn, but did not set any timeframe.

Nuclear stockpile numbers are closely guarded secrets in most nations that possess them, but private nuclear policy experts say no countries other than the U.S. and Russia are thought to have more than 300. The Federation of American Scientists estimates that France has about 300, China about 240, Britain about 225, and Israel, India and Pakistan roughly 100 each.

___

Associated Press writers Frank Jordans and Jim Kuhnhenn contributed to this report.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Source: http://news.yahoo.com/obama-renews-calls-nuclear-reductions-142815744.html

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Digital 3-D atlas of brain reveals tiny details

AAA??Jun. 20, 2013?3:12 PM ET
Digital 3-D atlas of brain reveals tiny details
By MALCOLM RITTERBy MALCOLM RITTER, AP Science Writer?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?

In this photo provided by Katrin Amunts, Karl Zilles, Alan C. Evans, researchers use a microtome to cut sections from a brain preserved in paraffin wax into slivers 20-micrometers thick, resulting in over 7,400 slices. A digital three-dimensional model called "BigBrain" was produced from the thousands of sections. Its resolution is finer than a human hair, so it can reveal clusters of brain cells and even some large individual cells. It is being made available to scientists around the world. The researchers, from Germany and Canada, reported their work Thursday, June 20, 2013 in the journal Science. (AP Photo/Katrin Amunts, Karl Zilles, Alan C. Evans)

In this photo provided by Katrin Amunts, Karl Zilles, Alan C. Evans, researchers use a microtome to cut sections from a brain preserved in paraffin wax into slivers 20-micrometers thick, resulting in over 7,400 slices. A digital three-dimensional model called "BigBrain" was produced from the thousands of sections. Its resolution is finer than a human hair, so it can reveal clusters of brain cells and even some large individual cells. It is being made available to scientists around the world. The researchers, from Germany and Canada, reported their work Thursday, June 20, 2013 in the journal Science. (AP Photo/Katrin Amunts, Karl Zilles, Alan C. Evans)

This image made from video provided by researchers shows a highly-detailed image of the hippocampus region of the human brain. The digital three-dimensional model called "BigBrain" was produced from the thousands of sections made from the brain of a 65-year-old woman. Its resolution is finer than a human hair, so it can reveal clusters of brain cells and even some large individual cells. It is being made available to scientists around the world. The researchers, from Germany and Canada, reported their work Thursday, June 20, 2013 in the journal Science. (AP Photo/Montreal Neurological Institute/McGill University, Institute of Neuroscience and Medicine/Research Centre Juelich, and National Research Council of Canada)

In this photo provided by Katrin Amunts, Karl Zilles, Alan C. Evans, researchers use a microtome to cut sections from a brain preserved in paraffin wax into slivers 20-micrometers thick, resulting in over 7,400 slices. A digital three-dimensional model called "BigBrain" was produced from the thousands of sections. Its resolution is finer than a human hair, so it can reveal clusters of brain cells and even some large individual cells. It is being made available to scientists around the world. The researchers, from Germany and Canada, reported their work Thursday, June 20, 2013 in the journal Science. (AP Photo/Katrin Amunts, Karl Zilles, Alan C. Evans)

In this photo provided by Katrin Amunts, Karl Zilles, Alan C. Evans, researchers arrange sections made from a brain preserved in paraffin wax. A digital three-dimensional model called "BigBrain" was produced from the thousands of sections. Its resolution is finer than a human hair, so it can reveal clusters of brain cells and even some large individual cells. It is being made available to scientists around the world. The researchers, from Germany and Canada, reported their work Thursday, June 20, 2013 in the journal Science. (AP Photo/Katrin Amunts, Karl Zilles, Alan C. Evans)

(AP) ? Scientists have a new brain atlas to help them study their favorite organ. It's a digital, three-dimensional model called "BigBrain."

Its resolution is finer than a human hair, so it can reveal clusters of brain cells and even some large individual cells. It is being made available to scientists around the world.

To make the atlas, researchers sliced a cadaver brain from a 65-year-old woman into 7,400 thin sections, stained them to reveal tiny features, and photographed each one. Then they used computers to combine the data into a 3-D digital model.

The idea of thin-slicing a brain to study its anatomy is not new. In fact, complete bodies of a man and a woman were sliced and photographed about 20 years ago to create an anatomy reference called the Visible Human Project.

For the new brain-mapping project, the researchers chose the woman's brain for no special reason other than it was basically healthy, said Katrin Amunts of Heinrich Heine University Duesseldorf in Germany.

She is lead author of a report on the atlas published Thursday in the journal Science. Scientists have begun mapping data from other brain studies onto the new model to gain new insights, said senior author Karl Zilles of the Juelich Aachen Research Alliance in Juelich, Germany.

___

Science: http://www.sciencemag.org

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-06-20-US-SCI-3-D-Brain/id-07e62fa921c2467db57d42f41d80b479

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Wednesday 19 June 2013

Exposure to high pollution levels during pregnancy may increase risk of having child with autism

June 18, 2013 ? Women in the U.S. exposed to high levels of air pollution while pregnant were up to twice as likely to have a child with autism as women who lived in areas with low pollution, according to a new study from Harvard School of Public Health (HSPH). It is the first large national study to examine links between autism and air pollution across the U.S.

"Our findings raise concerns since, depending on the pollutant, 20% to 60% of the women in our study lived in areas where risk of autism was elevated," said lead author Andrea Roberts, research associate in the HSPH Department of Social and Behavioral Sciences.

The study appeared online June 18, 2013 in Environmental Health Perspectives.

Exposure to diesel particulates, lead, manganese, mercury, methylene chloride and other pollutants are known to affect brain function and to affect the developing baby. Two previous studies found associations between exposure to air pollution during pregnancy and autism in children, but those studies looked at data in just three locations in the U.S.

The researchers examined data from Nurses' Health Study II, a long-term study based at Brigham and Women's Hospital involving 116,430 nurses that began in 1989. Among that group, the authors studied 325 women who had a child with autism and 22,000 women who had a child without the disorder. They looked at associations between autism and levels of pollutants at the time and place of birth. They used air pollution data from the U.S. Environmental Protection Agency to estimate women's exposure to pollutants while pregnant. They also adjusted for the influence of factors such as income, education, and smoking during pregnancy.

The results showed that women who lived in the 20% of locations with the highest levels of diesel particulates or mercury in the air were twice as likely to have a child with autism as those who lived in the 20% of areas with the lowest levels.

Other types of air pollution -- lead, manganese, methylene chloride, and combined metal exposure -- were associated with higher autism risk as well. Women who lived in the 20% of locations with the highest levels of these pollutants were about 50% more likely to have a child with autism than those who lived in the 20% of areas with the lowest concentrations.

Most pollutants were associated with autism more strongly in boys than girls. However, since there were few girls with autism in the study, the authors said this finding should be examined further.

Senior author Marc Weisskopf, associate professor of environmental and occupational epidemiology at HSPH, said, "Our results suggest that new studies should begin the process of measuring metals and other pollutants in the blood of pregnant women or newborn children to provide stronger evidence that specific pollutants increase risk of autism. A better understanding of this can help to develop interventions to reduce pregnant women's exposure to these pollutants."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/_Rz1cN_xQGk/130618101734.htm

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Mill Valley Real Estate Report (June 2013 Home Sales Update ...

Mill Valley Real Estate Report (June 2013 Home Sales Update) | Pacific Union. The Mill Valley, CA real estate market is reaching heights not seen for years (5 years, to be exact) with 43 single family home sales in May 2013. These properties sold for an average price of about $1.4 million and averaged 2,186 sq. ft. (or about $649 per sq. ft.). If you arecomparing these numbers to past market updates, you will quickly note the spike in sales prices and price per foot. Like all towns in Marin County, California (San Francisco?s ?North Bay? region), the number of Mill Valley home sales are being held back by a sheer lack of homes for sale ? buyers are eager to buy, but they have few options. Multiple offer situations are very common when it comes to fairly priced homes. My team has come to expect up to 15 offers for homes in the lower end. This momentum extends from the entry level (where investors are very actively pursuing a purchase and rent strategy) to the luxury home price points ? case in point: we have 6 luxury homes in escrow over $2 million in Mill Valley (this includes a magnificent estate currently pending at a price of $4.9 million). This market segment was virtually non-existant the last several years.

Coming Soon

815 Smith Road, Mill Valley

Nestled on a large, nearly 1-acre parcel, high above Mill Valley, sits a spectacular, tri-level, trophy home with impeccable views across Richardson Bay, high-level finishes, modern lines, superior privacy, and a resplendent energy all its own. Exclusively listed for $1,499,000. Call Kyle at (415) 350-9440 for a private showing.

As noted in virtually all of my market reports thus far in 2013, the number of listings actively on the market in Mill Valley is best characterized as being at a point of scarcity. As we move into the traditionally slow Summer months, there are only 53 properties active on the market in all of Mill Valley. The absorption rate in Mill Valley currently stands at just a shade over 1 month (6 months is considered ?balanced?).

Below are the percentages of homes in escrow in each of Mill Valley?s major price bands:
?63% of homes priced under $800,000;
?50% of homes between $801,000 and $1 million;
?53% of homes between $1 million and $1.5 million;
?50% of homes between $1.5 million and $2 million;
?25% of homes between $2 million and up.

Of the 43 homes that sold in May 2013:
?7 homes were priced under $800,000;
?23 homes priced from $800,000 to $1.5 million; and
?13 homes priced from $1.5 million and up.

MLS Listings in Tam Valley Homestead Valley, Sycamore Park, and Strawberry generated the most calls and showings this past month. If you would like me to run the exact numbers for your Mill Valley neighborhood or if you have any questions about Mill Valley schools or its many delightful communities, just give me a call at (415) 350-9440. My name is Kyle Frazier. I am a Top Agent, J.D., Broker, Realtor, Certified Residential Specialist (CRS), and a Certified Luxury Home Marketing Specialist (CLHMS), with Christie?s Great Estates | Pacific Union International Real Estate. It is always my pleasure to be of service.

Source: http://millvalley101.com/2013/06/mill-valley-real-estate-report-june-2013-home-sales-update-pacific-union/

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Good Reads: From teens and Facebook to the culinary tastes of ?Dear Leader? to a new 5G cellphone

This week's round-up of Good Reads includes Facebook losing favor among teens, the first menial jobs of the rich and famous, reminiscences by Kim Jong-il's sushi chef, new campuses for the headquarters of tech giants, and the world's fastest cellphone.

By Chris Gaylord,?Staff writer / June 11, 2013

Most teenagers have a Facebook account they check every day.

Nick Ut/AP

Enlarge

Fading enthusiasm for Facebook

Teenagers hate Facebook, according to a new study by the Pew?Internet & American Life Project. They also can?t get enough of it.?The report found that 94 percent of American teens are on?Facebook, more than on any other social network. But many of the young respondents have lost enthusiasm for the site, complaining about ?the increasing adult presence, people sharing excessively, and stressful ?drama.?? Despite these frustrations, teens say they keep using Facebook because it has become a key part of socializing.

Skip to next paragraph Chris Gaylord

Innovation Editor

Chris Gaylord is the Monitor's Innovation Editor. He loves gadgets, history, design, and curious readers like you.

Recent posts

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?I think Facebook can be fun, but also it?s drama central,? one girl told a Pew researcher. Another said: ?Honestly, I?m on it constantly but I hate it so much.??

While these findings might seem troubling, they also sound a lot like young people?s feelings about high school in general. The big difference is how the social network follows teens home. Pew found a significant rise in the kind of material that students share on Facebook compared with what was shared in 2006: 92 percent now reveal their real names, 91 percent post personal photos, 24 percent upload videos of themselves, 20 percent publish their phone numbers.?

What was your first job?

Does your first job define you? Kate Rockwood, writing for Fast Company, asked several major names in business and entertainment about where they began. The consensus: You can start from anywhere.?

Among our favorite first jobs in the illustrated slide show: Doug McMillon, chief executive officer of Wal-Mart International, started off unloading boxes in a Wal-Mart warehouse. Before directing the highest-grossing movie of all time (and then breaking his own record), James Cameron was a truck driver. Martha Stewart began as a $50-an-hour model for Chanel and others. Actress and writer Tina Fey kicked off her professional life answering phones at a suburban YMCA. And Liu Chuanzhi, cofounder of computer giant Lenovo, was a laborer in the rice fields during Mao?s Cultural Revolution.?

A sushi chef?s memory of the ?Dear Leader??

The world knows little about North Korea. As Adam Johnson writes in GQ magazine, ?We didn?t even know the age of the current leader, Kim Jong-un, until Kenji Fujimoto revealed his birth date. (January 8, 1983.)?

Who is Kenji Fujimoto? For 11 years, he was personal chef, confidant, and court jester to the supreme leader?s father, Kim Jong-il, and at times played nanny to a young Kim Jong-un. Now, after escaping North Korea and taking on an alias, Mr. Fujimoto is the ?Japanese intelligence community?s single greatest asset on the Kim family.?

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/wlke_B6kWqs/Good-Reads-From-teens-and-Facebook-to-the-culinary-tastes-of-Dear-Leader-to-a-new-5G-cellphone

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Tuesday 18 June 2013

Tackling a framework for surgical innovation

Tackling a framework for surgical innovation [ Back to EurekAlert! ] Public release date: 18-Jun-2013
[ | E-mail | Share Share ]

Contact: Gerard Farrell
gerard.farrell@hkstrategies.com
646-317-7401
Weill Cornell Medical College

Researchers offer new framework to improve the safety and effectiveness of surgical procedures and implantable devices

NEW YORK (June 18, 2013)-- An international team of investigators co-led by Weill Cornell Medical College is offering a new framework for evidence-based surgery and device research, similar to the kind of risk and benefit analysis used in evidence-based medicine.

"Currently, there is no dynamic research framework to systematically detect devices and surgeries that don't offer any benefits to patients or may even be harmful," says co-lead investigator Dr. Art Sedrakyan of Weill Cornell Medical College.

In the June 18 issue of the British Medical Journal (BMJ), Dr. Sedrakyan and his colleagues suggest ways that clinical trials, observational databases and registries can be used to provide quality assessment and surveillance of both surgery and the use of implanted medical devices.

"The failure to conduct methodologically rigorous studies has led to some devices/surgical interventions, such as metal-on-metal hip implants or robotic surgery, becoming popular without high quality supporting evidence," says Dr. Sedrakyan, associate professor of public health and cardiothoracic surgery at Weill Cornell. Dr. Sedrakyan worked with a team of researchers from the United Kingdom, and U.S. Food and Drug Administration (FDA) who are part of the IDEAL (Idea, Development, Exploration, Assessment, Long-term follow-up) Collaboration. This group is working on ways to improve research in surgery and on medical devices as a way to spur surgical excellence, as well as innovation.

At Weill Cornell Medical College, Dr. Sedrakyan leads the Medical Device Epidemiology Network's Science and Infrastructure Center, one of two FDA-funded centers in the country that evaluates medical devices, especially implantable devices. He is the vice-chair of the IDEAL Collaboration advancing device evaluation and, prior to joining Weill Cornell, has worked on post-market surveillance and modernization surveillance at the FDA.

Regulatory agencies in a number of countries, and surgeons themselves, are now seeking ways to address the current lack of evidence-based research in surgery and device fields, Dr. Sedrakyan says.

"We have to recognize that not every surgical procedure that is offered is as safe and effective as we thought and so these techniques need to be evaluated," Dr. Sedrakyan says. "In addition, new innovative research methods need to be developed that are quite different than those used for the evaluation of pharmaceuticals."

Research in Surgery

Unlike the way drugs are tested, it isn't easy to conduct randomized clinical trials in surgery.

For example, if medical investigators want to know if an experimental cancer drug is more effective than an agent being used in the clinic, they test the new drug against the old one in a randomized clinical trial. Randomly assigned patients use the new drug or old drug.

However, when surgeons are trained to perform a specific kind of operation or have a preference for a particular technique they can't be easily asked to conduct an alternative surgery or apply a different technique so that new and old methods can be compared in a randomized clinical trial. On top of that, there is a variation in the choice of medical devices.

"Historically, the focus of government-funded research has been on pharmaceuticals and often not surgical/device interventions, which has been limited as a consequence. Drugs have certainly dominated the agenda," says Dr. Sedrakyan.

But in their new study, researchers point out that there are methodological ways to use available data that will allow a researcher to compare the safety and effectiveness of different surgical techniques and devices. One method, highlighted in the study, involves the right way to scrutinize observational data that has already been collected within registries or other observational data sources. The study also suggests ways that clinical trials can be conducted in surgery and in the field of implantable devices.

"Our framework can potentially be used by agencies to guide regulatory science related to implantable devices. We can look at the performance of surgery and devices by recognizing the unique aspects of specific types of surgery and by developing robust new methods," says Dr. Sedrakyan.

###

Researchers contributing to the study include Dr. Jonathan Cook, the corresponding author, from the University of Aberdeen, UK; Dr. Peter McCulloch and Dr. David J. Beard from the University of Oxford, UK; Dr. Jane M. Blazeby, from the University of Bristol, UK; and Dr. Danica Marinac-Dabic from the U.S. FDA.

Dr. Sedrakyan's research is funded by the FDA. Other sources of funding for this study include the National Institute for Health Research in the UK, Health Technology Assessment programme in the UK, Johnson & Johnson, Medtronic and Zimmer (all unrestricted grants) to support an IDEAL workshop.

Weill Cornell Medical College

Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit weill.cornell.edu.

Office of External Affairs

Weill Cornell Medical College
tel: 646.317.7401
email: pr@med.cornell.edu
Follow WCMC on Twitter and Facebook
[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Tackling a framework for surgical innovation [ Back to EurekAlert! ] Public release date: 18-Jun-2013
[ | E-mail | Share Share ]

Contact: Gerard Farrell
gerard.farrell@hkstrategies.com
646-317-7401
Weill Cornell Medical College

Researchers offer new framework to improve the safety and effectiveness of surgical procedures and implantable devices

NEW YORK (June 18, 2013)-- An international team of investigators co-led by Weill Cornell Medical College is offering a new framework for evidence-based surgery and device research, similar to the kind of risk and benefit analysis used in evidence-based medicine.

"Currently, there is no dynamic research framework to systematically detect devices and surgeries that don't offer any benefits to patients or may even be harmful," says co-lead investigator Dr. Art Sedrakyan of Weill Cornell Medical College.

In the June 18 issue of the British Medical Journal (BMJ), Dr. Sedrakyan and his colleagues suggest ways that clinical trials, observational databases and registries can be used to provide quality assessment and surveillance of both surgery and the use of implanted medical devices.

"The failure to conduct methodologically rigorous studies has led to some devices/surgical interventions, such as metal-on-metal hip implants or robotic surgery, becoming popular without high quality supporting evidence," says Dr. Sedrakyan, associate professor of public health and cardiothoracic surgery at Weill Cornell. Dr. Sedrakyan worked with a team of researchers from the United Kingdom, and U.S. Food and Drug Administration (FDA) who are part of the IDEAL (Idea, Development, Exploration, Assessment, Long-term follow-up) Collaboration. This group is working on ways to improve research in surgery and on medical devices as a way to spur surgical excellence, as well as innovation.

At Weill Cornell Medical College, Dr. Sedrakyan leads the Medical Device Epidemiology Network's Science and Infrastructure Center, one of two FDA-funded centers in the country that evaluates medical devices, especially implantable devices. He is the vice-chair of the IDEAL Collaboration advancing device evaluation and, prior to joining Weill Cornell, has worked on post-market surveillance and modernization surveillance at the FDA.

Regulatory agencies in a number of countries, and surgeons themselves, are now seeking ways to address the current lack of evidence-based research in surgery and device fields, Dr. Sedrakyan says.

"We have to recognize that not every surgical procedure that is offered is as safe and effective as we thought and so these techniques need to be evaluated," Dr. Sedrakyan says. "In addition, new innovative research methods need to be developed that are quite different than those used for the evaluation of pharmaceuticals."

Research in Surgery

Unlike the way drugs are tested, it isn't easy to conduct randomized clinical trials in surgery.

For example, if medical investigators want to know if an experimental cancer drug is more effective than an agent being used in the clinic, they test the new drug against the old one in a randomized clinical trial. Randomly assigned patients use the new drug or old drug.

However, when surgeons are trained to perform a specific kind of operation or have a preference for a particular technique they can't be easily asked to conduct an alternative surgery or apply a different technique so that new and old methods can be compared in a randomized clinical trial. On top of that, there is a variation in the choice of medical devices.

"Historically, the focus of government-funded research has been on pharmaceuticals and often not surgical/device interventions, which has been limited as a consequence. Drugs have certainly dominated the agenda," says Dr. Sedrakyan.

But in their new study, researchers point out that there are methodological ways to use available data that will allow a researcher to compare the safety and effectiveness of different surgical techniques and devices. One method, highlighted in the study, involves the right way to scrutinize observational data that has already been collected within registries or other observational data sources. The study also suggests ways that clinical trials can be conducted in surgery and in the field of implantable devices.

"Our framework can potentially be used by agencies to guide regulatory science related to implantable devices. We can look at the performance of surgery and devices by recognizing the unique aspects of specific types of surgery and by developing robust new methods," says Dr. Sedrakyan.

###

Researchers contributing to the study include Dr. Jonathan Cook, the corresponding author, from the University of Aberdeen, UK; Dr. Peter McCulloch and Dr. David J. Beard from the University of Oxford, UK; Dr. Jane M. Blazeby, from the University of Bristol, UK; and Dr. Danica Marinac-Dabic from the U.S. FDA.

Dr. Sedrakyan's research is funded by the FDA. Other sources of funding for this study include the National Institute for Health Research in the UK, Health Technology Assessment programme in the UK, Johnson & Johnson, Medtronic and Zimmer (all unrestricted grants) to support an IDEAL workshop.

Weill Cornell Medical College

Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit weill.cornell.edu.

Office of External Affairs

Weill Cornell Medical College
tel: 646.317.7401
email: pr@med.cornell.edu
Follow WCMC on Twitter and Facebook
[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-06/wcmc-taf061813.php

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